ROLE OF IMMUNOGENETIC FACTORS IN EARLY DIAGNOSIS OF UROLITHIASIS IN CHILDREN

In recent years, one of the main aspects of studying the problem of urolithiasis in the world is the search for genetic risk factors for the development of urolithiasis: identification of its association with polymorphic variants of a particular gene. Objective. To study the association of interleukin-1β and interleukin-18 genes with the development of urolithiasis in children. Materials and methods. Clinical examination of 100 children with urolithiasis and 100 practically healthy children was carried out, as well as collection and analysis of statistical data on urolithiasis in the group of children of different age groups to identify sex, age, family frequency of urolithiasis, peculiarities of lifestyle and nutrition, as well as seasonality of this pathological process. Conducting ultrasound and radiological examination of urinary organs of patients. The selection of patients for the study of gene polymorphism was carried out on the basis of the diagnosis made in the clinic and written consent of the proband. Blood samples were collected from patients with USD (100 samples) and a control group of practically healthy children (100 samples). The results obtained in this study indicate that the IL-1β gene contributes to the determination of disorders
contributing to the development of USD in children. In particular, in children of Uzbek population genetic markers of predisposition to USD are genotype CC of IL-1β gene. It is considered reasonable to include testing of this genotype in a comprehensive USD prevention programme in Uzbekistan. Conclusion. The results obtained in this study indicate that the genetic variant CC genotype of IL-1β gene affects manifestation, duration of course, recurrences and clinical and functional features of the course of urolithiasis and can be used for early diagnosis and early diagnosis of the disease in children of Uzbek population.